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Resveratrol is absorbed in the small intestine as resveratrol glucuronide.
It is suggested that resveratrol is most likely to be in the form of a glucuronide conjugate after crossing the small intestine and entering the blood circulation, which will have important implications for the biological functions of resver atrol in vivo. Expand
Novel biomarkers of the metabolism of caffeic acid derivatives in vivo.
The results reveal isoferulic acid (and possibly dihydroferulic acid) as novel markers of caffeoyl quinic acid metabolism and shows a highly significant excretion increase postsupplementation. Expand
Epicatechin and catechin are O-methylated and glucuronidated in the small intestine.
The activity of catechol-O-methyl transferases in the metabolism of flavanols is demonstrated and suggests that these metabolites and conjugates are likely to enter the portal vein. Expand
Epicatechin and its in vivo metabolite, 3'-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation.
The results provide the first evidence that 3'-O-methyl epicatechin inhibits cell death induced by hydrogen peroxide and that the mechanism involves suppression of caspase-3 activity as a marker for apoptosis. Expand
Epicatechin and its in vivo metabolite, 3