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Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.
TLDR
This polypeptide shows a high degree of evolutionary conservation, exhibiting close structural, functional, and immunological similarity when isolated from such diverse origins as cells of mammals and higher plants, and so may well be a universal constituent of living cells.
Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen*
TLDR
It is reported that two alternate signaling pathways of protein kinase C activation involving either the lipid second messengers (diacylglycerol and its mimetics, the phorbol esters) or reactive oxygen converge at the zinc finger of the regulatory domain.
Isolation of a murine Ly‐6 cDNA reveals a new multigene family.
TLDR
To isolate a Ly‐6 cDNA, synthetic oligonucleotides, based on the partial amino acid sequence of purified Ly‐ 6E.1 protein, were used to probe a cDNA library to enable further molecular genetic analysis of the role ofLy‐6‐linked proteins in the process of T lymphocyte activation.
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis
TLDR
It is shown that retinol is essential for the metabolic fitness of mitochondria, illuminating a hitherto unsuspected role of vitamin A in mitochondrial bioenergetics of mammals, acting as a nutritional sensor.
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP‐1‐dependent energy deprivation
TLDR
The data highlight a novel regulatory role of vitamin A in mitochondrial energy homeostasis and cause oxidative stress, mitochondrial dysfunction, and PARP‐1‐dependent energy deprivation following vitamin A depletion.
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria.
TLDR
The results indicate that oxidation of PKCδ is key to the activation of the pathway, and define the molecular mechanisms underlying the signaling function of PK cδ in mitochondria.
Rapid immunodiagnosis of cytomegalovirus pneumonia by bronchoalveolar lavage using human and murine monoclonal antibodies.
TLDR
Bronchoalveolar lavage material from 54 immunocompromised patients with interstitial pneumonia was examined by immunofluorescence with cytomegalovirus-specific monoclonal antibodies, and a clear correlation was seen between the number of fluorescent cells and the presence of cytomeGalovirus pneumonia.
Immunotherapy of murine leukemias by monoclonal antibody. I. Effect of passively administered antibody on growth of transplanted tumor cells.
TLDR
Monoclonal antibody of the appropriate immunoglobulin subclass can be effective in controlling tumor growth if administered in the optimal treatment regimen, but inherent features of the tumor cell ultimately determine whether abrogation or enhancement of growth will occur.
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