Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
- P. G. Arnison, M. Bibb, W. A. van der Donk
- Biology, ChemistryNatural product reports (Print)
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
Antifouling activity of brominated cyclopeptides from the marine sponge Geodia barretti.
- M. Sjögren, U. Göransson, L. Bohlin
- Chemistry, BiologyJournal of Natural Products
- 5 February 2004
The potent antifouling effects of two compounds isolated from the marine sponge Geodia barretti are shown, hypothesize that the isolated compounds are part of the sponge's chemical defense to deter fouling organisms.
Cyclotides: a novel type of cytotoxic agents.
- P. Lindholm, U. Göransson, A. Backlund
- Biology, ChemistryMolecular Cancer Therapeutics
- 1 April 2002
Activity profiles of the cyclotides differed significantly from those of antitumor drugs in clinical use, which may indicate a new mode of action in cytotoxic activities of naturally occurring macrocyclic peptides isolated from the two violets.
Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids.
- H. El‐Seedi, Asmaa M. A. El-Said, R. Verpoorte
- Chemistry, BiologyJournal of Agricultural and Food Chemistry
- 30 October 2012
The chemistry, biosynthesis, natural sources, dietary intake, and pharmacokinetic properties of hydroxycinnamic acids are discussed.
Distribution and Evolution of Circular Miniproteins in Flowering Plants[W]
- C. Gruber, Alysha G. Elliott, D. Craik
- BiologyThe Plant Cell Online
- 1 September 2008
It is predicted that the number of cyclotide within the Rubiaceae may exceed tens of thousands, potentially making cyclotides one of the largest protein families in the plant kingdom.
Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.
- K. Rosengren, R. Clark, N. Daly, U. Göransson, Alun Jones, D. Craik
- Biology, ChemistryJournal of the American Chemical Society
- 20 September 2003
It is shown here that in fact the peptide does not have a head-to-tail cyclic structure but rather a side chain to backbone cyclization between Glu8 and the N-terminus, which creates an embedded ring that is threaded by the C-terminal tail of the molecule, forming a noose-like feature.
Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption.
- R. Burman, A. Strömstedt, M. Malmsten, U. Göransson
- Biology, ChemistryBiochimica et Biophysica Acta
- 1 November 2011
Cytotoxic potency of small macrocyclic knot proteins: structure-activity and mechanistic studies of native and chemically modified cyclotides.
- R. Burman, A. Herrmann, U. Göransson
- Biology, ChemistryOrganic and biomolecular chemistry
- 18 May 2011
A systematic test of mixtures of cyclotides revealed that they act in an additive way, and found that while the Glu residue is very important in maintaining the activity of the bracelet cyclotide cycloviolacin O2, it is much less important in the Möbius cyclotide.
The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima.
- H. El‐Seedi, R. Burman, U. Göransson
- BiologyJournal of Ethnopharmacology
- 13 February 2013
Distribution and Evolution of Circular Miniproteins in Flowering Plants
- C. Gruber, A. Elliott, David J. Craika
- Political Science
Christian W. Gruber,a,1 Alysha G. Elliott,a David C. Ireland,a Piero G. Delprete,b,2 Steven Dessein,c Ulf Göransson,d Manuela Trabi,a,3 Conan K. Wang,a Andrew B. Kinghorn,a Elmar Robbrecht,c and…