Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides
- U. Fuhrmann, E. Bause, G. Legler, H. Ploegh
- Biology, ChemistryNature
- 23 February 1984
In vivo dMM inhibits the equivalent of the mannosidase IA/B activities and blocks conversion of high-mannose to complex oligosaccharides, which could prove to be a powerful way to manipulate carbohydrate structure in vivo.
Drospirenone: a Novel Progestogen with Antimineralocorticoid and Antiandrogenic Activity
- P. Muhn, U. Fuhrmann, K. Fritzemeier, R. Krattenmacher, E. Schillinger
- Biology, MedicineAnnals of the New York Academy of Sciences
- 1 June 1995
Drospirenone exerts potent progestogenic and antigonadotropic activity which was studied in various animal species and efficiently promotes the maintenance of pregnancy in ovariectomized rats, inhibits ovulation in rats and mice and stimulates endometrial transformation in the rabbit.
The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential.
- U. Fuhrmann, R. Krattenmacher, E. Slater, K. Fritzemeier
- Biology, MedicineContraception
- 1 October 1996
Antiproliferative effects of progesterone antagonists and progesterone receptor modulators on the endometrium
- K. Chwalisz, R. Brenner, U. Fuhrmann, H. Hess-Stumpp, W. Elger
- Biology, MedicineSteroids
- 1 October 2000
Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist.
- U. Fuhrmann, H. Hess-Stumpp, K. Chwalisz
- Biology, ChemistryJournal of Medicinal Chemistry
- 7 December 2000
The chemical synthesis and pharmacological characterization of a novel, highly potent progesterone receptor (PR) antagonist, ZK 230211, which showed high antiprogestagenic activity on both PR isoforms PR-A and PR-B and displayed only marginal antiglucocorticoid effects.
Gangliosides mediate inhibitory effects of tetanus and botulinum A neurotoxins on exocytosis in chromaffin cells.
- P. Marxen, U. Fuhrmann, H. Bigalke
- Biology, ChemistryToxicon
In vitro characterization of ZK 230211—A type III progesterone receptor antagonist with enhanced antiproliferative properties
- W. Afhüppe, J. Beekman, C. Möller
- BiologyJournal of Steroid Biochemistry and Molecular…
- 1 March 2010
Inhibitors of oligosaccharide processing.
- U. Fuhrmann, E. Bause, H. Ploegh
- Chemistry, MedicineBiochimica et Biophysica Acta
- 24 June 1985
Misexpression of wild-type and truncated isoforms of the high-mobility group I proteins HMGI-C and HMGI(Y) in uterine leiomyomas.
- M. Klotzbücher, A. Wasserfall, U. Fuhrmann
- BiologyAmerican Journal of Pathology
- 1 November 1999
A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques.
- M. Peluffo, J. Stanley, R. Stouffer
- Biology, MedicineHuman Reproduction
- 1 July 2014
This is the first study to demonstrate that a PTGER2 antagonist can serve as an effective non-hormonal contraceptive in primates, and this is a proof-of-concept study in a non-human primate model.