Many cuts to ruin: a comprehensive update of caspase substrates
This review summarizes the known caspase substrates comprising a bewildering list of more than 280 different proteins and highlights some recent aspects inferred by the cleavage of certain proteins in apoptosis.
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options
Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3-HLF ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids, anthracyclines and agents in clinical development.
New Approaches and Therapeutics Targeting Apoptosis in Disease
convincing proof-of-principle evidence obtained in several animal models confirms the validity of strategies targeting apoptosis and revealed an enormous potential for therapeutic intervention in a variety of illnesses.
Multiple virulence factors are required for Staphylococcus aureus‐induced apoptosis in endothelial cells
The results indicate that the ability of S. aureus to induce apoptosis in endothelial cells is determined by multiple virulence factors.
Unscheduled Akt-Triggered Activation of Cyclin-Dependent Kinase 2 as a Key Effector Mechanism of Apoptin's Anticancer Toxicity
CDK2 is identified as the principal kinase that phosphorylates apoptin and is crucially required for apoptin-induced cell death, and Immortalized CDK2-deficient fibroblasts and CDK 2 knockdown cells were markedly protected against apoptin.
Unique and overlapping substrate specificities of caspase-8 and caspase-10
It is demonstrated that caspase-10 and -8 have overlapping cleavage preferences for several substrates such as the kinases RIP and PAK2, and this suggests that these caspases also have selective substrate cleavage specificities and might thereby exert nonredundant roles in apoptosis signaling.
Apoptosis-based therapies and drug targets
This review outlines the recent advances in the field of apoptosis-based therapies and explores some highlights of a very active field of drug development.
The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy.
This is the first report of a Vps45-related disease in humans, manifesting by neutropenia, thrombasthenia, myelofibrosis, and progressive bone marrow failure.
Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.
Autoimmune cytopenia is a frequent manifestation of primary immunodeficiencies. Two siblings presented with Evans syndrome, viral infections, and progressive leukopenia. DNA available from one…
Increased hepatotoxicity of tumor necrosis factor–related apoptosis‐inducing ligand in diseased human liver
Clinical trials should be performed with great caution when TRAIL is combined with chemotherapy or administered to patients with inflammatory liver diseases, and enhanced sensitivity of diseased liver was associated with an increased expression of TRAIL receptors and up‐regulation of proapoptotic Bcl‐2 proteins.