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Experimental evidence against the mitochondrial theory of aging A study of isolated human skeletal muscle mitochondria
TLDR
The present results are incompatible with the mitochondrial theory of aging, and the central bioenergetic systems appeared unaltered with age. Expand
Lactate dehydrogenase is not a mitochondrial enzyme in human and mouse vastus lateralis muscle
TLDR
It was concluded that skeletal muscle mitochondria are devoid of LDH and unable to metabolize lactate. Expand
Human quadricepts muscle mitochondria: A functional characterization
TLDR
Comparison of uncoupled rates of respiration and state 3 rates indicated that the ATP synthesis exerted major flux control over respiration of succinate + glutamate, malate + glutamate and pyruvate + malate, which could be used as a functional assay of ATP synthesis. Expand
Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly
TLDR
It is suggested that lifelong endurance exercise training ensures an improved oxidative capacity of skeletal muscle, and that skeletal muscle of elderly subjects maintains the ability to respond to acute endurance exercise. Expand
Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity
TLDR
The mitochondrial capacities were far in excess of whole-body performance and were related to physical activity, but not to age, and the mitochondrial theory of ageing is incompatible with these results. Expand
Aerobic metabolism of human quadriceps muscle: in vivo data parallel measurements on isolated mitochondria.
TLDR
Strong correlations were obtained between VO2max and a number of mitochondrial parameters (mitochondrial protein, cytochrome aa3, citrate synthase, and respiratory activities) and the respiratory chain activity appeared sufficient. Expand
The oxidation of added NADH by intact heart mitochondria
TLDR
A NADH-oxidase which was destroyed upon ageing of the mitochondria and which was highly sensitive to the normal respiratory chain inhibitors is described, which possesses some of the characteristics which might be expected from a cytoplasmicmitochondrial NADh-oxidsase working in Go. Expand
Optimization of preparation of mitochondria from 25-100 mg skeletal muscle.
TLDR
It was observed that the homogenization procedure exerts strong control on the integrity of the isolated mitochondria. Expand
Oxygen solubilities of media used in electrochemical respiration measurements.
TLDR
Solubility data are presented as equations from which the oxygen concentration of arbitrary media may be calculated with an accuracy of about 1% and it is concluded that the former method produces reliable results provided that some simple precautions are taken. Expand
SMALL SCALE PREPARATION OF SKELETAL MUSCLE MITOCHONDRIA, CRITERIA OF INTEGRITY, AND ASSAYS WITH REFERENCE TO TISSUE FUNCTION
TLDR
Mitochondria prepared in small scale from skeletal muscle were studied with respiration measurements and low temperature spectroscopy and showed cytochrome c conservation, a most useful test parameter. Expand
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