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Nitric oxide synthases: regulation and function.
Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as substrates andExpand
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Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO· synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS oxidizes itsExpand
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Regulation of the Expression of Inducible Nitric Oxide Synthase
Abstract Nitric oxide (NO), generated by the inducible isoform of nitric oxide synthase (iNOS), has been described to have beneficial microbicidal, antiviral, antiparasital, immunomodulatory, andExpand
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Nitric oxide and oxidative stress in vascular disease
  • U. Förstermann
  • Biology, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 21 March 2010
Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the intima. AnExpand
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Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hyperglycemia is the major causal factor in the development of endothelial dysfunction in patients with diabetes mellitus. Although the mechanisms underlying this phenomenon are likely to beExpand
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Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling
Angiotensin II infusion causes endothelial dysfunction by increasing NAD(P)H oxidase-mediated vascular superoxide production. However, it remains to be elucidated how in vivo angiotensin II treatmentExpand
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Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.
Three isozymes of nitric oxide (NO) synthase (EC 1.14.13.39) have been identified and the cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells), II (inExpand
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Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III)
Nitric oxide synthase (NOS) exists in three established isoforms. NOS I (NOS1, ncNOS) was originally discovered in neurons. This enzyme and splice variants thereof have since been found in many otherExpand
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Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.
Incubation of human A549/8 cells with human interleukin-1 beta (50 units/ml), interferon-gamma (100 units/ml), and tumor necrosis factor-alpha (10 ng/ml) (cytomix) resulted in a marked expression ofExpand
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Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies
  • U. Förstermann
  • Medicine
  • Nature Clinical Practice Cardiovascular Medicine
  • 1 June 2008
Endothelial cells control vascular homeostasis by generating paracrine factors that regulate vascular tone, inhibit platelet function, prevent adhesion of leukocytes, and limit proliferation ofExpand
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