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K+‐channel inhibition reduces portal perfusion pressure in fibrotic rats and fibrosis associated characteristics of hepatic stellate cells
In liver fibrosis, activated hepatic stellate cells (HSC) secrete excess extracellular matrix, thus, represent key targets for antifibrotic treatment strategies. Intermediate‐conductance Ca2 +Expand
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The Elongated First Fibronectin Type III Domain of Collagen XIV Is an Inducer of Quiescence and Differentiation in Fibroblasts and Preadipocytes*
Collagen XIV (CXIV) is a fibril-associated collagen that is mainly expressed in well differentiated tissues and in late embryonic development. Because CXIV is almost absent in proliferating and/orExpand
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(+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9
SummaryHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Treatment options, especially in advanced tumor stages, are still limited. Inhibition of signaling cascadesExpand
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T-cell Composition in Ileal and Colonic Creeping Fat – Separating Ileal from Colonic Crohn’s Disease
Background and Aims Creeping fat [CF] is a hyperplasia of adipose tissue adjacent to inflamed intestine in Crohn's disease [CD]. Data from genome-wide association studies [GWAS] distinguished Crohn'sExpand
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Accelerated tumour metastasis due to interferon‐γ receptor‐mediated dissociation of perivascular cells from blood vessels
  • C. Ni, P. Ma, +7 authors Z. Qin
  • Biology, Medicine
  • The Journal of pathology
  • 25 May 2017
Angiostasis mediated by interferon (IFN)‐γ is a key mechanism of anti‐tumour immunity; however, the effect of IFN‐γ on host vascular endothelial growth factor A (VEGFA)‐expressing cells during tumourExpand
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Doxorubicin‐induced cardiotoxicity involves IFNγ‐mediated metabolic reprogramming in cardiomyocytes
Immune responses contribute to a large extent to heart diseases. However, it is still not clear how the key inflammatory mediator interferon‐γ (IFNγ) plays a role in doxorubicin (DOX)‐inducedExpand
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Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines
PurposeThe taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisiteExpand
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Einfluss proinflammatorischer Zytokine auf die Expression von humanem ß2-Defensin in Darmepithelien — In-vitro-Untersuchungen im Modell mit der epithelialen Zelllinie HT-29
In Crohn’s disease an altered intestine mucosal barrier and cellular cytokine-mediated immune responses against commensal flora was described before. Taking part in the barrier function, humanExpand