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Plasma concentrations in pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerized curve fitting.
- E. Weidekamm, H. Plozza-Nottebrock, I. Forgó, U. Dubach
- Bulletin of the World Health Organization
For the determination of the plasma concentration profiles of pyrimethamine and sulfadoxine after the administration of 1 tablet of Fansidar, highly specific analytical methods are needed as the… Expand
Epidemiologic study of abuse of analgesics containing phenacetin. Renal morbidity and mortality (1968-1979).
A study group of 623 working women 30 to 49 years old with objective evidence of intake of phenacetin-containing analgesics and a matched control group of 621 women without such intake in 1968 were… Expand
Pharmacokinetics of cefetamet (Ro 15-8074) and cefetamet pivoxil (Ro 15-8075) after intravenous and oral doses in humans.
- J. Koup, U. Dubach, R. Brandt, R. Wyss, K. Stoeckel
- Chemistry, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 April 1988
This report summarizes the results of three pharmacokinetic studies of cefetamet and cefetamet pivoxil conducted in normal adult male volunteers. In the first study the pharmacokinetics of cefetamet… Expand
Pharmacokinetics of tenoxicam in healthy human volunteers.
- R. Heintz, T. Guentert, J. Enrico, U. Dubach, R. Brandt, F. Jeunet
- European journal of rheumatology and inflammation
Tenoxicam, a thieno-thiazine derivative, belongs to a new chemical class of non-steroidal anti-inflammatory drugs. Single dose kinetics was investigated after intravenous and oral administration to… Expand
Isolation of a homogeneous glucosidase II from pig kidney microsomes.
The processing of the oligosaccharide precursor chain, (GlcNAc)2(Man)9(Glc)3, of N-glycosylated glycoproteins starts with the action of glucosidase I which excises the terminal (alpha 1-2)-linked… Expand
Pharmacokinetic studies with chlorthalidone (hygroton®) in man
- W. Riess, U. Dubach, D. Burckhardt, W. Theobald, P. Vuillard, M. Zimmerli
- Chemistry, Medicine
- European Journal of Clinical Pharmacology
- 16 December 1977
SummaryThe kinetics of chlorthalidone in blood and urine were analysed in one group of 6 healthy volunteers after single oral doses of 50, 100 and 200 mg, as well as in a second group of 6 volunteers… Expand
Differential enzymatic behaviour of single proximal segments of the superficial and juxtamedullary nephron
SummaryWith oxidoreductases mediating several metabolic pathways, e.g. LDH (glycolysis), ICDH, MDH (tricarboxylic acid cycle), GLDH (aminoacid metabolism) and G-6-PDH (hexose monophosphate shunt)… Expand
High frequency of human immunodeficiency virus-associated autonomic neuropathy and more severe involvement in advanced stages of human immunodeficiency virus disease.
We conducted a controlled trial to determine frequency and severity of autonomic neuropathy in patients infected with the human immunodeficiency virus (HIV). We studied 25 HIV-seropositive patients… Expand
An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987)
BACKGROUND Phenacetin abuse is known to produce kidney disease; salicylate use is supposed to prevent cardiovascular disease. We conducted a prospective, longitudinal epidemiologic study to examine… Expand