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In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
The results of previous in vitro experiments indicate that a glycosylphosphatidylinositol (GPI)-anchored protein may play an important role in the guidance of temporal retinal axons during theExpand
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Modulation of EphA Receptor Function by Coexpressed EphrinA Ligands on Retinal Ganglion Cell Axons
The Eph family is thought to exert its function through the complementary expression of receptors and ligands. Here, we show that EphA receptors colocalize on retinal ganglion cell (RGC) axons withExpand
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Shared and distinct functions of RAGS and ELF‐1 in guiding retinal axons
Two ligands for Eph‐related receptor tyrosine kinases, RAGS and ELF‐1, have been implicated in the control of development of the retinotectal projection. Both molecules are expressed in overlappingExpand
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Opposing Gradients of Ephrin-As and EphA7 in the Superior Colliculus Are Essential for Topographic Mapping in the Mammalian Visual System
During development of the retinocollicular projection in mouse, retinal axons initially overshoot their future termination zones (TZs) in the superior colliculus (SC). The formation of TZs isExpand
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Src Family Kinases Are Involved in EphA Receptor-Mediated Retinal Axon Guidance
EphA receptor tyrosine kinases and their ephrin ligands play important roles in wiring of the developing nervous system. We have investigated here the function of Src family kinases (SFKs) in theExpand
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Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish.
The isolation and characterisation of two zebrafish Eph receptor ligand cDNAs which we have called zfEphL3 and zfEphL4 is described. These genes are expressed in the presumptive midbrain ofExpand
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A role for the EphA family in the topographic targeting of vomeronasal axons.
We have investigated the role of the Eph family of receptor tyrosine kinases and their ligands in the establishment of the vomeronasal projection in the mouse. Our data show intriguing differentialExpand
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Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression
BACKGROUND Expression of the homeobox-containing gene Engrailed (En) in an increasing rostral-to-caudal gradient in the dorsal mesencephalon is the earliest known marker for polarity of the chickExpand
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The Eph family in retinal axon guidance
The continued functional characterization of Eph-related receptors and ligands has provided further information toward an understanding of the mechanisms controlling the retinotectal projection.Expand
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Ephrin-As as receptors in topographic projections
The Eph family of receptor tyrosine kinases and their 'ligands', the ephrins, have been implicated in a large number of developmental processes, such as boundary formation, cell migration, axonExpand
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