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MMP-12, MMP-3, and TIMP-1 Are Markedly Upregulated in Chronic Demyelinating Theiler Murine Encephalomyelitis
Abstract Theiler murine encephalomyelitis (TME) represents a highly relevant viral model for multiple sclerosis. Matrix metalloproteinases (MMPs) degrade extracellular matrix molecules and areExpand
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Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis
Theiler’s murine encephalomyelitis is an experimentally virus‐induced inflammatory demyelinating disease of the spinal cord, displaying clinical and pathological similarities to chronic progressiveExpand
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Revised guides for organ sampling and trimming in rats and mice--part 1.
This is the first part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies. It is based on the experience made inExpand
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Diagnostic efficiency of troponin T measurements in rats with experimental myocardial cell damage.
A cardioselective parameter has been available for about 2 years since the development by KATUS of an immunoassay for cardiac Troponin T (TnT). The major advantages of this TnT assay are itsExpand
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Identification of genes involved in gentamicin-induced nephrotoxicity in rats--a toxicogenomic investigation.
For the application of microarray technology as an additional endpoint in toxicological studies, there is a need to understand associations between pathological processes and gene expressionExpand
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Mycobacterium avium subsp. hominissuis Infection in 2 Pet Dogs, Germany
To the Editor: The genus Mycobacterium contains various obligate and opportunistic pathogens of animals, which may also be transmitted to humans and cause disease in, thus exhibiting a considerableExpand
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Distinct Spatio‐Temporal Extracellular Matrix Accumulation within Demyelinated Spinal Cord Lesions in Theiler's Murine Encephalomyelitis
The accumulation of extracellular matrix (ECM) and glial scar formation are considered important factors for the failure of regeneration in central nervous system (CNS) injury and multiple sclerosis.Expand
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Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease
SummaryAfter intracerebral infection with Borna disease virus adult Lewis rats develop a virus-induced immunopathological reaction resulting in severe neurological symptoms and a non-purulentExpand
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Transcriptomic Meta-Analysis of Multiple Sclerosis and Its Experimental Models
Background Multiple microarray analyses of multiple sclerosis (MS) and its experimental models have been published in the last years. Objective Meta-analyses integrate the information from multipleExpand
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Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro
Macrophages are a heterogeneous cell population playing a pivotal role in tissue homeostasis and inflammation, and their phenotype strongly depends on the micromilieu. Despite its increasingExpand
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