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Synaptic structural dynamics and aging.
Synaptic junctional areas are not immutable structures, on the contrary, they are remodelled throughout the individual's lifespan as a consequence of environmental stimulations. This adaptiveExpand
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Inverse correlation between mitochondrial size and metabolic competence: a quantitative cytochemical study of cytochrome oxidase activity
Mitochondria are topologically closed bilayered systems where the synthesis of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate occurs via oxidativeExpand
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beta-Amyloid fragment 25-35 induces changes in cytosolic free calcium in human platelets.
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Deterioration threshold of synaptic morphology in aging and senile dementia of Alzheimer's type.
OBJECTIVE To search for a deterioration threshold of synaptic ultrastructure in physiologic aging and senile dementia of Alzheimer's type (SDAT). STUDY DESIGN The numerical density (Nu), averageExpand
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Vitamin E deficiency as a model of precocious brain aging: assessment by X-ray microanalysis and morphometry.
Vitamin E (alpha-tocopherol) is a known biological antioxidant able to quench the lipid peroxidation chain and to protect the cellular structures (e.g., plasma membranes) from the attack of freeExpand
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Age-dependent decrease in the activity of succinic dehydrogenase in rat CA1 pyramidal cells: a quantitative cytochemical study
A computer-assisted morphometric study has been carried out on the ultrastructure of perikaryal CA1 pyramidal cell mitochondria positive to the copper ferricyanide cytochemical reaction for succinicExpand
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Morphologic changes in cerebellar mitochondria during aging.
OBJECTIVE To seek age-dependent morphofunctional changes in mitochondrial metabolic competence in the rat cerebellum. STUDY DESIGN Three-, 12- and 24-month-old female Wistar rats were used for theExpand
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Impaired succinic dehydrogenase activity of rat Purkinje cell mitochondria during aging
The perikaryal Purkinje cell mitochondria positive to the copper ferrocyanide histochemical reaction for succinic dehydrogenase (SDH) have been investigated by means of semiautomatic morphometricExpand
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Acetylcarnitine modulation of the morphology of rat hippocampal synapses.
OBJECTIVE To measure the effect of chronic administration of acetylcarnitine (ALCAR) on the morphologic plasticity of rat hippocampal synapses. STUDY DESIGN Computer-assisted morphometry wasExpand
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Quantitative cytochemistry of succinic dehydrogenase activity in rat mitochondria.
OBJECTIVE To set up a computer-assisted morphometric procedure to cytochemically measure the activity of succinic dehydrogenase (SDH). STUDY DESIGN In rat mitochondria from Purkinje cell perikaryaExpand
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