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Thin-layer chromatographic determination of barbiturates and phenytoin in serum and blood.
A method is described for the measurement of blood, serum and/or plasma levels of hexobarbital, phenobarbital, cyclobarbital and phenytoin by ultraviolet reflectance photometry on thin-layerExpand
  • 15
  • 1
Formation of identical metabolites from piperazine- and dimethylamino-substituted phenothiazine drugs in man, rat and dog.
Abstract Degradation of the piperazine ring in the phenothiazine drugs perazine, trifluoperazine, fluphenazine, prochlorperazine and perphenazine in vivo leads to the formation ofExpand
  • 26
  • 1
Phenobarbital-induced prolongation of half-life and alteration of distribution of a phenothiazine drug metabolite in the rat.
Abstract Male rats recieved a repeated oral treatment with perazine which led to an accumulation of the metabolite N -[ γ -(phenothiazinyl-10)-propyl]ethylenediamine (PPED). When phenobarbital wasExpand
  • 5
  • 1
Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism
  • U. Breyer
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
SummaryMale rats were treated orally for 7 days with perazine, chlorpromazine, imipramine or phenobarbital. Isolated liver microsomes were tested for their metabolic activities towards perazine,Expand
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  • 1
Urinary metabolites of 10-[3'-(4"-methylpiperazinyl)-propyl]-phenothiazine (perazine) in psychiatric patients. I. Isolation, identification and determination of metabolites.
  • U. Breyer
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1 April 1969
Abstract From the urine of patients receiving daily 300–600 mg of perazine drug metabolites have been extracted and separated by thin-layer chromatography. Metabolic conversions taking place includeExpand
  • 33
Metabolism and disposition of trifluoperazine in the rat. I. A thin-layer chromatographic method for the measurement of trifluoperazine and its metabolites in rat tissues.
A method has been developed for quantitative measurement of trifluoperazine and its metabolites, 7-hydroxytrifluoperazine and desmethyltrifluoperazine, in rat organs. Trifluoperazine sulfoxide couldExpand
  • 22
Tissue metabolites of trifluoperazine, fluphenazine, prochlorperazine, and perphenazine in the rat: indentification and synthesis.
Rats were treated chronically with increasing doses of trifluoperazine, prochlorperazine, fluphenazine, or perphenazine per os, and drug metabolites were extracted from their livers, kidneys, andExpand
  • 15
Metabolism of the phenothiazine drug perazine by liver and lung microsomes from various species.
  • U. Breyer
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1 December 1971
The oxidative metabolism of perazine was studied in vitro, using solvent extraction and thin layer chromatography followed by spectrophotometry for determination of the metabolites. Liver microsomesExpand
  • 28
Kinetics of [3H]trifluoperazine in bile fistula rats.
1. Anaesthetized male rats with a bile fistula received 12-3 micron mol/kg [9-3H]tri-fluoperazine into the tail vein, and the biliary excretion of total radioactivity, unchanged drug and phenolicExpand
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