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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma andExpand
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.
An understanding of the differences and similarities of the retinoid X receptor (RXR) and retinoic acid receptor (RAR) systems requires knowledge of the diversity of their family members, theirExpand
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR
The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). WeExpand
The germ cell nuclear factor mGCNF is expressed in the developing nervous system.
Using a reinoic acid receptor hybridization probe, we have isolated a mouse embryonic cDNA that encodes the germ cell nuclear factor (mGCNF). The in vitro translated protein binds specifically to theExpand
Viral myb oncogene encodes a sequence-specific DNA-binding activity
The retroviral oncogene v-myb and its cellular progenitor c-myb encode nuclear DNA-binding proteins1–5. Myb genes have been identified in a broad range of species, including vertebrates6–9, the fruitExpand
A mouse cdc25 homolog is differentially and developmentally expressed.
The timing and activation of the p34cdc2 kinase in mammals is associated with dephosphorylation of phosphotyrosine and phosphothreonine residues on the p34cdc2 kinase. For fission yeast, the timingExpand
The murine AE4 promoter predominantly drives type B intercalated cell specific transcription
AE4 is an anion exchanger almost exclusively expressed in the collecting ducts of the kidney. This very restricted expression prompted us to analyze its transcription in more detail. 5′ RACE yieldedExpand
A Multiple Sclerosis–Associated Variant of CBLB Links Genetic Risk with Type I IFN Function
Multiple sclerosis (MS) is an autoimmune disease of the CNS, and autoreactive CD4+ T cells are considered important for its pathogenesis. The etiology of MS involves a complex genetic trait andExpand
The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of replication, and the BK virus enhancer.
TGGCA-binding proteins are nuclear proteins with high affinity for double-stranded DNA homologous to the prototype recognition sequence 5'YTGGCANNNTGCCAR 3'. Their ubiquitous tissue distribution inExpand
Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma.
Estrogen-related receptor gamma (ERRgamma) is an orphan nuclear receptor highly expressed in heart, skeletal muscle, kidney, and brain. To identify activation function-1 (AF-1)-dependent cofactorsExpand