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Modulation of voltage‐gated channel currents by harmaline and harmane
It is concluded that harmaline and harmane are modulators of ICa(V) in vitro, which might be related to their neuroprotective effects. Expand
Moclobemide: therapeutic use and clinical studies.
  • U. Bonnet
  • Psychology, Medicine
  • CNS drug reviews
  • 1 March 2003
Moclobemide is a reversible inhibitor of monoamine-oxidase-A (RIMA) and has been extensively evaluated in the treatment of a wide spectrum of depressive disorders and less extensively studied inExpand
Lack of Efficacy of Naltrexone in the Prevention of Alcohol Relapse: Results From a German Multicenter Study
The safety but not the efficacy of naltrexone in prevention of alcohol relapse is confirmed and the question arises whether self-reports of drinking are more reliable than γ-GT as a measure of recent alcohol consumption. Expand
Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neurones
It is concluded that the selective inhibition of NHE3 acidifies and activates CO2/H+-sensitive neurones within the ventrolateral medulla oblongata. Expand
CO2‐sensitive medullary neurons: activation by intracellular acidification
It is suggested that intracellular rather than extra-cellular acidification activates CO2-sensitive neurons, and this results in neuronal discharge which were first suppressed and then accelerated. Expand
Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones
It is demonstrated that application of the weak acid propionate transiently lowers intracellular pH (pH(i)) of BCECF-AM loaded CA3-neurones in hippocampal slices, which supports the hypothesis that pH(i) contributes to the control of cortical excitability. Expand
Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro
This work screened a panel of currently used neuropsychopharmaca for comparable effects on intracellular pH and found that moclobemide, an antidepressant, and also some antiepileptic drugs can reduce neuronal pHi in hippocampus slices in vitro. Expand
How addictive are gabapentin and pregabalin? A systematic review
The addiction risks of gabapentin and pregabalin are compared with those of traditional psychoactive substances and recommend that in patients with a history of SUD, gabAPentinoids should be avoided or if indispensable, administered with caution by using a strict therapeutic and prescription monitoring. Expand
Treatment of alcohol withdrawal syndrome with gabapentin.
Four in-patients with moderate alcohol-withdrawal syndromes benefited from treatment with gabapentin administered in an add-on fashion to clomethiazole, and it is believed that the potential value of gapapentin in alcohol withdrawal deserves further controlled studies. Expand
Alteration of intracellular pH and activity of CA3-pyramidal cells in guinea pig hippocampal slices by inhibition of transmembrane acid extrusion
The powerful inhibitory and anticonvulsive properties of NHE- and NCHE-inhibitors are very likely based upon intracellular acidification - as derived from the previous findings that a moderate increase in intrACEllular free protons is sufficient to reduce membrane excitability of CA3-neurones. Expand