Share This Author
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network
The placebo response in medicine: minimize, maximize or personalize?
- P. Enck, U. Bingel, M. Schedlowski, W. Rief
- Psychology, MedicineNature Reviews Drug Discovery
- 1 March 2013
Three strategies that could be used to modulate the placebo response, depending on which stage of the drug development process they are applied are discussed.
The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil
- U. Bingel, V. Wanigasekera, I. Tracey
- Psychology, MedicineScience Translational Medicine
- 16 February 2011
Using sophisticated brain imaging techniques, the authors show that one’s expectation of the success of a pain treatment can markedly influence its effectiveness, and how divergent expectancies alter the analgesic efficacy of a potent opioid in healthy volunteers by using brain imaging.
Anterior Insula Integrates Information about Salience into Perceptual Decisions about Pain
- K. Wiech, Chia-shu Lin, K. H. Brodersen, U. Bingel, M. Ploner, I. Tracey
- Psychology, BiologyThe Journal of Neuroscience
- 1 December 2010
Evidence is provided that the anterior insula and MCC as a “salience network” integrate information about the significance of an impending stimulation into perceptual decision-making in the context of pain.
Direct Evidence for Spinal Cord Involvement in Placebo Analgesia
Results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.
Imaging CNS modulation of pain in humans.
Recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro- and anti-nociceptive mechanisms may contribute to the development or maintenance of chronic pain states.
Habituation to painful stimulation involves the antinociceptive system
Changes in brain gray matter due to repetitive painful stimulation