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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
TLDR
A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+. Expand
A family of mammalian Na+-dependent L-ascorbic acid transporters
TLDR
It is found that SVCT1 and SVCT2 each mediate concentrative, high-affinity L-ascorbic acid transport that is stereospecific and is driven by the Na+ electrochemical gradient. Expand
Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*
TLDR
The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium. Expand
Molecular Characterization of a Broad Selectivity Neutral Solute Channel*
TLDR
The expression cloning of a liver cDNA encoding a unique promiscuous solute channel (AQP9) that confers high permeability for both solute and water is reported, defining a new evolutionary branch of the major intrinsic protein family of aquaporin proteins and describing a previously unknown mechanism by which a large variety of solutes and water can pass through a single pore. Expand
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
TLDR
It is indicated that the small RNA‐binding fraction of IRP1, which is insensitive to cellular iron status, contributes to basal mammalian iron homeostasis, whereas IRP2 is sensitive to iron status and can compensate for the loss of IRp1 by increasing its binding activity. Expand
The Glutamate Transporter GLT1a Is Expressed in Excitatory Axon Terminals of Mature Hippocampal Neurons
TLDR
The originally cloned form ofGLT1, GLT1a, is expressed as protein in neurons in the mature hippocampus and may contribute significantly to glutamate uptake into excitatory terminals. Expand
Behavioral and anatomical abnormalities in Mecp2 mutant mice: A model for Rett syndrome
TLDR
This study provides the first evidence that the abnormal motor and cognitive behavioral phenotype in Mecp2 mice is consistent with specific volume reductions in brain regions associated with these behaviors, and shows how these data parallel the human condition. Expand
Expression of the iron transporter ferroportin in synaptic vesicles and the blood–brain barrier
TLDR
The widespread representation of ferroportin at sites such as the blood-brain barrier and synaptic vesicles raises the possibility that trafficking of elemental iron may be instrumental in the distribution of iron in the central nervous system. Expand
Human calcium transport protein CaT1.
TLDR
A role for hCaT1 in cellular calcium uptake in a variety of tissues, including the transcellular calcium transport pathway in intestine, is suggested. Expand
CaT1 expression correlates with tumor grade in prostate cancer.
TLDR
This work reports that the gene for CaT1, a channel protein highly selective for Ca(2+), is expressed at high levels in human PCa and in the LNCaP PCa cell line, and suggests thatCaT1 may be a novel target for therapy. Expand
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