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Isolation, Phylogenetic Analysis and Anti-infective Activity Screening of Marine Sponge-Associated Actinomycetes
Results show a high diversity of actinomycetes associated with marine sponges as well as highlight their potential to produce anti-infective agents.
Diversity, abundance and natural products of marine sponge-associated actinomycetes.
- U. Abdelmohsen, K. Bayer, U. Hentschel
- Biology, Environmental ScienceNatural product reports
- 11 February 2014
This review focuses on the diversity, abundance and methodological approaches targeting marine sponge-associated actinomycetes, and novel qPCR data on actInomycete abundances in different sponge species and other environmental sources are presented.
Actinomycetes from Red Sea Sponges: Sources for Chemical and Phylogenetic Diversity
- U. Abdelmohsen, Chen Yang, H. Horn, D. Hajjar, T. Ravasi, U. Hentschel
- Biology, EngineeringMarine drugs
- 1 May 2014
Marine sponges are a prolific resource for novel bioactive actinomycetes with potential for drug discovery and PCR-based screening for biosynthetic genes showed that 20 act inomycete isolates encoded each at least one type of biosynthetics gene.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
- A. Owis, M. El-Hawary, Dalia El Amir, O. Aly, U. Abdelmohsen, M. Kamel
- BiologyRSC advances
- 20 May 2020
This study provides a scientific basis for the health benefits of the regular use of S. persica as it leaches bioactive flavonoids in the aqueous saliva.
An Enrichment of CRISPR and Other Defense-Related Features in Marine Sponge-Associated Microbial Metagenomes
Data suggest that defense is an important functional trait for an existence within sponges that requires mechanisms to defend against foreign DNA from microorganisms and viruses, and contributes to an understanding of the evolutionary arms race between viruses/phages and bacterial genomes.
Elicitation of secondary metabolism in actinomycetes.
Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163
- Yousef Dashti, T. Grkovic, U. Abdelmohsen, U. Hentschel, R. Quinn
- Biology, ChemistryMarine drugs
- 1 May 2014
Two sponge-derived actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163, were grown in co-culture and the presence of induced metabolites monitored by 1H NMR. Ten known compounds,…
Potential of marine natural products against drug-resistant bacterial infections.
Cytokinins Mediate Resistance against Pseudomonas syringae in Tobacco through Increased Antimicrobial Phytoalexin Synthesis Independent of Salicylic Acid Signaling1[W][OA]
A novel transgenic approach enabling autoregulated cytokinin synthesis in response to pathogen infection showed that cytokinins mediate enhanced resistance against the virulent hemibiotrophic pathogen Pseudomonas syringae pv tabaci.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
This poster presents a small number of potential drug candidates derived from natural sources for the development of anti-SARS CoV-2 therapeutics that have shown the potential to be useful in the treatment of SARS.