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Fluorescent fusion proteins have revolutionized examination of proteins in living cells. Still, studies using these proteins are met with criticism because proteins are modified and ectopically expressed, in contrast to immunofluorescence studies. However, introducing immunoreagents inside cells can cause protein extraction or relocalization, not reflecting(More)
EpCAM [epithelial cell adhesion molecule; CD326 (cluster of differentiation 326)] is highly expressed on epithelium-derived tumours and can play a role in cell proliferation. Recently, RIP (regulated intramembrane proteolysis) has been implicated as the trigger for EpCAM-mediated proliferative signalling. However, RIP does not explain all EpCAM-derived(More)
Mutations in the epithelial cell adhesion molecule (EpCAM; CD326) gene are causal for congenital tufting enteropathy (CTE), a disease characterized by intestinal abnormalities resulting in lethal diarrhea in newborns. Why the different mutations all lead to the same disease is not clear. Here, we report that most mutations, including a novel intronic(More)
Ultrastructural examination of cells and tissues by electron microscopy (EM) yields detailed information on subcellular structures. However, EM is typically restricted to small fields of view at high magnification; this makes quantifying events in multiple large-area sample sections extremely difficult. Even when combining light microscopy (LM) with EM(More)
This paper presents calculations of a pulverized coal flame and a coal-fired utility boiler with advanced combustion technologies. A combustion model based on an extended Eddy Dissipation Concept (EDC) combined with finite rate chemistry is described and some applications are shown. This model can be regarded as an extension of the previously used Eddy(More)
We prove that for a densest packing of more than three d–balls, d ≥ 3, where the density is measured by parametric density, the convex hull of their centers is either linear (a sausage) or at least 3–dimensional. This is also true for restrictions to lattice packings. The proofs require a Lagrange–type theorem from number theory and Minkowski's theory of(More)
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