U. Scherdin

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The karyotypic and phenotypic stability of cultured rat fibrosarcoma cells was challenged by infection with Moloney murine sarcoma virus (MoMuSV). After transformation, the spindle-like morphology of the parental HH-16 cl.2/1 cells had altered to a rounded phenotype, which was maintained in tumors produced by inoculating transformed cells into congenic(More)
Permanent alterations of the epithelial differentiation pattern were investigated after infection of HH-16 cl. 4 adenocarcinoma cells with Moloney murine sarcoma virus (MoMuSV). Transformed cell clones with fibroblastoid morphology were isolated and compared with clones of unchanged epithelioid phenotype. Southern blot analyses showed intact MoMuSV proviral(More)
Cloned cell strains with adverse patterns of differentiation obtained from 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor tissue were used to study the effects of glucocorticoid hormones on morphology and proliferation. HH-16 clone 2/1 cells apparently reflecting mesenchymal cells of the stromal part of the mammary gland grow as elongated, mostly(More)
Due to the peculiar type of replication and genome structure, retroviruses (RNA tumor viruses) are characterized by an intensive interaction with the genome of the infected cell. For replication, transcription of the viral RNA genome into double-stranded DNA and subsequent integration of the viral information into the cellular genome are requisite. The(More)
In cultures of KNS-62 cells derived from a human lung squamous cell carcinoma, the initial growth arrest in the continuous presence of interferon-gamma (IFN-gamma) turned to cytopathic effects after 2 days of treatment. The remaining viable cells showed grossly distorted morphology, with enlargement and extensions up to 5 cell diameters. The presence of(More)
We have analyzed the transcriptional activity of cellular target sequences for Moloney murine leukemia virus integration in mouse fibroblasts. At least five of the nine random, unselected integration target sequences studied showed direct evidence for transcriptional activity by hybridization to nuclear run-on transcripts prepared from uninfected cells. At(More)
I D E N T I F I C A T I O N O F M O T I L I T Y FACTORS P R O D U C E D BY RAT AND H U M A N M A M M A R Y C A R C I N O M A CELLS. H. Kopdag, U. Scherdin, T. Rau and F. Hrlzel. Objective: Cellular motility plays an important role in embryogenesis, wound healing and metastasizing of tumor cells. A number of normal and neoplastic cell types produce motility(More)
Motility factors, e.g. SF/HGF (scatter factor/hepatocyte growth factor) or AMF (autocrine motility factor) can influence the migration of tumor cells in vitro and may facilitate invasive growth and metastases in vivo. The production of motility factors was studied in cell lines derived from human cholangiocarcinomas. Culture supernatants from 5 different(More)
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