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MicroRNAs (miRNAs) are 20–22 nucleotides long small non-coding RNAs that regulate gene expression post-transcriptionally. Last decade has witnessed emerging evidences of active roles of miRNAs in tumor development, progression, metastasis, and drug resistance. Many factors contribute to their dysregulation in cancer, such as chromosomal aberrations,(More)
MicroRNAs (miRNAs) are 20–22-nucleotide small endogenous non-coding RNAs which regulate gene expression at post-transcriptional level. In the last two decades, identification of almost 2600 miRNAs in human and their potential to be modulated opened a new avenue to target almost all hallmarks of cancer. miRNAs have been classified as tumor suppressors or(More)
Tumor cells develop drug resistance which leads to recurrence and distant metastasis. MicroRNAs are key regulators of tumor pathogenesis; however, little is known whether they can sensitize cells and block metastasis simultaneously. Here, we report miR-644a as a novel inhibitor of both cell survival and EMT whereby acting as pleiotropic therapy-sensitizer(More)
Several recent studies have demonstrated the benefits of using the Wireless Sensor Network (WSN) technology in largescale monitoring applications, such as planetary exploration and battlefield surveillance. Sensor nodes generate continuous stream of data, which must be processed and delivered to end users in a timely manner. This is a very challenging task(More)
Dysregulation of PI3K and MAPK pathways promotes uncontrolled cell proliferation, apoptotic inhibition and metastasis. Individual targeting of these pathways using kinase inhibitors has largely been insufficient due to the existence of cross-talks between these parallel cascades. MicroRNAs are small non-coding RNAs targeting several genes simultaneously and(More)
Current research in high value-added manufacturing processes, such as the Micro Injection Molding (μIM) process, focuses on the monitoring of the machine process data., which could potentially affect the quality of the end product. Up until now, machine process monitoring has been limited to the machine level and has often bypassed the ambient(More)
Advanced Persistent Threat (APT) is one of the most serious types of cyber attacks, which is a new and more complex version of multistep attack. Within the APT life cycle, continuous communication between infected hosts and Command and Control (C&C) servers is maintained to instruct and guide the compromised machines. These communications are usually(More)
Whilst the concept of IoT has already started to expand to some industrial environments, one industrial environment which still has not much exposure is the plastics industry environment made up of the Injection Moulding (IM), Micro Injection Moulding (μIM) and Extrusion line manufacturing processes. These processes would directly benefit from the IoT(More)
In this paper, we present a new secure message transmission scheme using hyperchaotic discrete primary and auxiliary chaotic systems. The novelty lies on the use of auxiliary chaotic systems for the encryption purposes. We have used the modified Henon hyperchaotic discrete-time system. The use of the auxiliary system allows generating the same keystream in(More)
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