U-R Heinrich

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Hearing impairment caused by ototoxic insults, such as noise or gentamicin is a worldwide health problem. As the molecular circuitries involved are not yet resolved, current otoprotective therapies are rather empirical than rational. Here, immunohistochemistry and western blotting showed that the cytoprotective protein survivin is expressed in the human and(More)
Guanylyl cyclases (GC) catalyze the formation of the intracellular signal molecule cyclic GMP from GTP. For some years it has been known that the heme-containing soluble guanylyl cyclase (sGC) is stimulated by NO and NO-containing compounds. The sGC enzyme consists of two subunits (alpha(1) and beta(1)). In the present study, the alpha(1) and(More)
It is well established that decorative cosmetics can enhance female facial attractiveness. In this study, we investigated the effects of a cleanser and a decent foundation on attractiveness of female faces. Comparative rating of a set of facial photographs by a group of lay persons revealed that the cleansing product was significantly reducing the(More)
Gentamicin treatment induces hair cell death or survival in the inner ear. Besides the well-known toxic effects, the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway was found to be involved in cell protection. After gentamicin application, the spatiotemporal expression patterns of Akt and its activated form (p-Akt) were determined in male guinea pigs.(More)
Short case histories of twin sisters with progressive juvenile kyphoscoliosis who were incorrectly brought up and finally scorned as "witches" by their parents are used as examples to explain that Minutio existinationis (M.e.) can be regarded as a severe psychological trauma. The article seeks an approach for therapy. Rehabilitation of the two patients(More)
Field potentials and the reflection spectra of cytochromes were continuously recorded from the olfactory cortical slice of a guinea pig which was incubated under the normoxic and anoxic conditions. The reduction of the oxidated spectra of the cytochromes occurred before the decrease of field potential heights and the oxidation of the reduced spectra(More)
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