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The behavioural and biochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, dizocilpine and memantine, and the competitive NMDA receptor antagonist, CGP 39551, were investigated in rats. Systemic injections of dizocilpine (0.33 mg/kg) increased locomotion and rearing in an open field, whereas memantine (20 mg/kg)(More)
We investigated the effects of a bilateral quinolinic acid lesion of the medial entorhinal cortex (EC) on acquisition of a spatial learning task. During reversal of the same task, we challenged the animals by the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801). Training took postoperatively place in an eight-arm radial maze in which(More)
The acetylcholinesterase inhibitor tetrahydroaminoacridine (THA) is known to interact with neurotransmitter systems other than the cholinergic, e.g. several studies have shown interaction of THA with the N-methyl-D-aspartate (NMDA) receptor subtype of the glutamatergic system. We therefore investigated whether behavioral changes in rats, caused by the(More)
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