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The nucleotide sequences of the SH gene and its F gene flanking region were determined over a range of 322 nucleotides for two live vaccines, two vaccine-associated isolates, six wild mumps viruses, and an attenuated mumps virus and compared to other sequences already published. Comparison revealed that the vaccine strains were clearly different from each(More)
 Genetic relationships of the prototype Bastianni strain of 1958 and of 13 echovirus type 30 (ECV30) isolates associated with meningitis cases in Germany during a period from 1966 to 1997 were investigated using direct sequencing of amplicons derived from a part of the capsid protein VP1 gene. Sequences were aligned both with each other and with known(More)
BACKGROUND/AIMS A novel virus, GB virus-C (GBV-C), with a genome organization similar to those of the Flaviviridae family was identified in sera of patients diagnosed with hepatitis. Up to now little has been known about the prevalence of GBV-C sequences in German hepatitis C virus infected patients. METHODS We investigated two groups of patients(More)
Die weltweit in großer genetischer Vielfalt kozirkulierenden, hochinfektiösen und Umwelteinflüssen gegenüber recht widerstandsfähigen humanen Caliciviren verursachen neben vereinzelten Infektionen sehr oft regelrechte Gastroenteritisausbrüche. Sie verbreiten sich durch Kontamination von Nahrungsmitteln oder Wasser sowie durch direkte Personenkontakte sowohl(More)
BACKGROUND AND OBJECTIVES The infectiousness and clinical relevance of the newly discovered blood-borne Flaviviridae-like agent, termed hepatitis G virus (HGV), are not well understood. MATERIALS AND METHODS Twenty-three transfusion recipients of two HGV-affected long-term blood donors were studied for HGV genome and antibodies to the putative envelope 2(More)
 Genetic relationships among echovirus type 25 (ECV 25) isolates associated with aseptic meningitis in Germany 1997/98 and a 40-year-old ECV 25 prototype strain were investigated using RT-PCR and direct sequencing the VP1/2A gene junction region. Sequences were compared to each other and to nonpolio enterovirus representatives (phylogenetic analysis). The(More)
 The molecular epidemiology of small round structured viruses (SRSVs) in Germany was studied using fecal specimens from 16 SRSV-associated gastroenteritis outbreaks in different parts of Germany during 1997/1998 by reverse transcription-polymerase chain reaction (RT-PCR) and by sequencing of the ORF1 and ORF3 amplicons. The majority of the isolates(More)
Ten mumps virus isolates recovered during an epidemic in Switzerland between Autumn 1992 and Spring 1993 were compared by nucleotide sequence analysis of the SH gene. The isolates were found to belong to two distinct yet closely related wild type strains in a newly identified European mumps virus lineage.
A report is presented about studies on poliovirus type 3 isolates from vaccine-associated cases or contacts of cases of paralytic poliomyelitis, observed over a period of 30 years in East Germany (former GDR). In the viral isolates, some mutations were found in comparison to the Sabin vaccine type 3 strain, distributed over the whole genome. The(More)