U Köllhofer

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Presynaptic events in the brain, such as neurotransmitter synthesis and release, may change during ageing or by performance of an operant behavior. Therefore, we measured the acetylcholine synthesis and release, and the dopamine release in brain tissue from different groups of rats. Male Sprague-Dawley rats, 4-5 or 16-17 months old, were housed individually(More)
In rat cerebral cortex slices we investigated the Ca2+ dependency of noradrenaline release and the influence of inorganic and organic Ca2+ antagonists. Slices were preincubated with 3H-noradrenaline and then superfused with noradrenaline-free medium. Release of 3H-noradrenaline was elicited by electrical pulses. The stimulation-evoked release was dependent(More)
Slices from rat brain occipital cortex were preincubated with [3H]noradrenaline then superfused and stimulated electrically. W-7, 10 mumol/l, enhanced the stimulation-evoked overlow. Binding experiments with W-7 evidenced weak displacement of [3H]yohimbine and no displacement of [3H]prazosin. Release experiments with the addition of clonidine, cocaine or(More)
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