U. Jayaswal

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The assessment of granulocyte chemotaxis is complicated by the difficulty of precisely reproducing results in serial estimations and deciding on the best end point which would reflect most accurately the degree of travel taken by the cells under observation. The methods in use are generally based on the Boyden chamber, following this, we have further(More)
The unusual lymphocytes from a case of chronic lymphatic leukaemia are described in terms of surface morphology and ultrastructure. Surface blebs were found to consist of nuclear material surrounded by plasma membrane. On the information available it was not possible to determine whether these were due to cell motility or nuclear extrusion.
Surface receptors on peripheral blood lymphocytes have been studied in 43 cases with chronic lymphocytic leukaemia (CLL), and five cases with lymphoma and overspill. One quarter of the cases with CLL had lymphocytes with no detectable surface immunoglobulin (SIg) by direct fluorescent antibody staining. The remainder had SIgM, which was associated with SIgD(More)
A detailed study is described of a case of hairy cell leukaemia, presenting with a serum paraprotein of an immunoglobulin (Ig) class different from that synthesised by the neoplastic cells. The case was unusual in its association with leukaemic arthropathy but ultrastructurally the hairy cells were typical. By immunofluorenscence and immuno-electron(More)
It has been suggested that dipyrimadole might be effective in reducing the incidence of thrombosis by interfering with both platelet clumping and the early stages of blood clotting. Emmons et al (1965 a & b) found that dipyrimadole inhibited thrombus formation in injured rabbit vessels in vivo, and reduced platelet stickiness in vitro, and they suggested(More)
The sera of 74 individuals with chronic lymphoproliferative disease were screened for the presence of inhibitory activity against neutrophil chemotaxis. This was present in more than half the patients with IgA myeloma and Hodgkin's disease but was less common in chronic lymphocytic leukaemia, lymphocytic lymphoma and non-IgA paraproteinaemia. Heating the(More)
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