U E Salazar-Morales

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BACKGROUND AND PURPOSE This study establishes a pharmacokinetic/pharmacodynamic (PK/PD) model to describe the time course and in vivo mechanisms of action of the antinociceptive effects of lumiracoxib, evaluated by the thermal hyperalgesia test in rats. EXPERIMENTAL APPROACH Female Wistar fasted rats were injected s.c. with saline or carrageenan in the(More)
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