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We have identified cDNAs clones for several cold-inducible mRNAs from the brown adipose tissue of mice. pCIN-1, a plasmid with a 900-base pair insert, encoded the mitochondrial uncoupling protein (UCP) as determined by the ability of the cDNA insert to select, by hybridization, an mRNA that could be translated into a 32,000-Da protein immunoprecipitable(More)
Epithelial cultures established from adult rat liver and from rat hepatomas induced in vivo with aromatic amine carcinogens have been compared by light and electron microscopy and by growth properties in liquid medium and in agar. The morphology and growth patterns of all of these cultures indicate that they have characteristics of epithelial rather than(More)
The kevels of sw-gIyceral-3-pbsphate dehydrogenase (GPDHj were determined in the brown adipose tissue (BAT) of different inbred strains of mice. The BAT d the B-FeLB/cJ strain contains twice as much enzyme activity per milfigram protein as do other strains. The appearance of this difference is developentatty dependent, since it is not detected in BAT until(More)
We have isolated from a BALB/c genomic library a 17.5-kilobase (kb) DNA fragment containing the entire mouse sn-glycerol-3-phosphate dehydrogenase (glycerol-P dehydrogenase) gene, and a substantial portion of the flanking regions. The DNA sequence of 10.8 kb of this fragment was determined. Using this information, together with the DNA sequence of several(More)
Serum levels of LH are used as marker of a number of pathological conditions. In the past many methods (RIA, IRMA, ELISA) have been employed to measure serum LH, these procedures, however, suffer from the drawback that they determine the immuno reactive and not the bioactive part of the hormone. An improved in vitro bioassay method for the estimation of(More)
The medical literature and our own observations show the importance of x-ray examinations to diagnose colon carcinoma. The conventional barium enema examination without double contrast is not suitable for a general medical check-up. In contrast to the diagnostic value of the conventional procedure, the diagnostic accuracy of double contrast examination is(More)
The levels of sn-glycerol-3-phosphate dehydrogenase (GPDH) were determined in the brown adipose tissue (BAT) of different inbred strains of mice. The BAT of the BALB/cJ strain contains twice as much enzyme activity per milligram protein as do other strains. The appearance of this difference is developmentally dependent, since it is not detected in BAT until(More)
Type C RNA viruses are present in cell cultures from transplantable and primary hepatomas induced by aromatic amine carcinogens. Virus yield was markedly enhanced by treating the cells with bromodeoxyuridine. Preparations of rat hepatoma-associated virus obtained from cultures treated with this compound were deficient in DNA polymerase activity.
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