U. Bürger

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Plasma amino acid concentrations and the elimination of parenterally administered amino acids were investigated in 12 patients with nonhypercatabolic acute renal failure. A distinctive plasma amino acid pattern could be observed: plasma concentrations of phenylalanine and methionine were increased, those of valine and leucine decreased. Of the nonessential(More)
Elimination of parenterally administered amino acids was investigated in patients with chronic renal failure (CRF) (10 on conservative treatment = CT, 13 on regular hemodialysis therapy = HD). In a bolus injection protocol 0.1 g amino acids as a 10% solution containing essential and nonessential amino acids were infused and pharmacokinetic parameters of 17(More)
The aim of our studies was to clarify, which dose of taurine should be added to amino acid solutions, in order to achieve plasma levels in premature infants as they are found during nutrition with mother's milk. In 22 premature infants born in the 30th-35th week of gestation plasma taurine levels during parenteral nutrition were measured on the 5th-9th day(More)
The fasting levels of free amino acids were determined in the serum of 23 premature and 7 small-for-dates newborns during the first 4 weeks of life. This was done by ion-exchange chromatography after ultrafiltration of the serum, which allowed quantification. Differences were recognized in regards to age, and nutritional state: 1. Small-for-dates newborns(More)
Thirty-three premature infants receiving parenteral nutrition during the first 5 days of life were divided into three groups. Infants in group I (n = 13) received no ventilatory therapy. Those in groups II (n = 10) and III (n = 10) were intubated and artificially ventilated because of hyaline membrane disease, apnea, or other illness. All infants received(More)
  • U Bürger
  • 1981
The postoperative and posttraumatic period is characterized by alterations of amino acid metabolism which sometimes lead to pronounced blood level imbalances. To investigate the cause of these alterations, we performed pharmacokinetic amino acid utilization studies in 20 patients on the second postoperative day and in 19 healthy adult volunteers. The(More)
The composition of an amino acid solution for intravenous use in newborns is discussed in the light of the metabolic kinetics of its constituents. Such a solution would be optimal when based on the transfer characteristics of the single amino acids used. Under these circumstances one would avoid imbalances in the respective blood levels. In particular, the(More)
The cytokines has been shown to be released shortly after the onset of septic shock and to return to base values some hours later (Hess DG Surg Gynecol Obstet 166:147 1988, Michie HR N Engl J Med 318:1481 1988). Currently, the two main cytokins i.e. 11 -1 and TNF is regarded to play an important role in the acute inflammatory reaction resulting in the(More)