U. A. Murashova

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The kinetics of 1-(2-phenylethyl)-4-phenylaminopiperidine acylation with propionyl chloride in nonaqueous solutions to form fentanyl hydrochloride have been studied experimentally using high-performance liquid chromatography (HPLC). It is established that the reaction is second order. The kinetics and activation parameters of the reaction have been(More)
We present a comparative analysis of the methods for quality evaluation and standardization of the parent substance of fentanyl based on foreign pharmacopoeias and domestic regulations. Harmonization of the tests and norms is proposed for the sections identification, determination of foreign impurities, and quantification. The harmonization is carried out(More)
Fentanyl, or 1-(2-phenylethyl)-4-(N-propionylphenylamino)piperidine, was originally described by Janssen [1] in1959 and is still among the most important drugs. This compound, being an agonist of -opioid receptors, is a narcotic short-term analgesic agent whose effect is 100 times that of morphine. Fentanyl is widely used in anesthesiology and reanimatology(More)
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