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Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) plays key roles in both the regulation of gene expression and the replication of the EBV genome in latently infected cells. To characterize the RNA-binding activity of EBNA-1, it was demonstrated that EBNA-1 binds efficiently to RNA homopolymers that are composed of poly(G) and weakly to those composed of(More)
The historical context surrounding the birth of the DARPA High Productivity Computing Systems (HPCS) program is important for understanding why federal government agencies launched this new, longterm high performance computing program and renewed their commitment to leadership computing in support of national security, large science, and space requirements(More)
We examine students' commonsense understanding of computer science concepts before they receive any formal instruction in the field. Specifically, we asked students on the first day of a CS1 class to describe in English how they would arrange a set of numbers in ascending, sorted order. We repeated the experiment with students in an introductory economics(More)
Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft. Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, eBooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr als 8(More)
We examine students' commonsense understanding of computer science concepts before they receive any formal instruction in the field. For this study, we asked students on the first day of a CS1 class to describe in English how they would arrange a set of numbers in ascending, sorted order; we then repeated the experiment asking students to sort a list of(More)
Ordering the columns of a nonsymmetric sparse matrix can reduce the fill created in its factorization. Minimum-degree is a popular heuristic for ordering symmetric matrices; a variant that can be used to order nonsymmetric matrices is called column minimum degree. In this paper we describe the design of a multithreaded approximate column minimum degree(More)
We evaluate the effectiveness of neural networks as a tool for predicting whether a particular combination of preconditioner and iterative method will correctly solve a given sparse linear system Ax = b. We consider several scenarios corresponding to different assumptions about the relationship between the systems used to train the neural network and those(More)
This paper reports a multinational , multi-institutional study to investigate Computer Science students' understanding of software design and software design criteria. Student participants were recruited from two groups: students early in their degree studies and students completing their Bachelor degrees. Computer Science educators were also recruited as a(More)
We report on responses to a series of four questions designed to identify pre-existing abilities related to debugging and troubleshooting experiences of novice students before they begin programming instruction. The focus of these questions include general troubleshooting, bug location, exploring unfamiliar environments, and describing students' real life(More)
What measurable effect do the language and paradigm used in early programming classes have on novice programmers' ability to do design? This work investigates the question by using data collected from 136 "first competency" students as part of a multi-national, multi-institutional study of students' approach to and attitudes toward design. Analysis of a(More)