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Pregnancy in patients on chronic dialysis: a single center experience and combined analysis of reported results.
OBJECTIVE(S) Pregnancy is rare in patients on chronic dialysis, with only a 30-50% rate of successful delivery reported in a previous review article. The pregnancy outcome has improved in recentExpand
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Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate.
Glutamate, an important central excitatory neurotransmitter, is also secreted by osteoblasts and may be involved in the regulation of bone metabolism. Glutamate receptors for N-methyl-D-aspartateExpand
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Upregulation of heme oxygenase‐1 inhibits the maturation and mineralization of osteoblasts
Heme‐oxygenase‐1 (HO‐1), an important enzyme involved in vascular disease, transplantation, and inflammation, catalyzes the degradation of heme into carbon monoxide and biliverdin. It has beenExpand
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Enhancement of PLGF production by 15-(S)-HETE via PI3K-Akt, NF-κB and COX-2 pathways in rheumatoid arthritis synovial fibroblast.
Metabolites from arachidonic acids play the pivotal roles in inflammatory arthritis. Arachidonic acid could be metabolized by cyclooxygenase (COX) and lipoxygenase (LOX) to produce the bioactiveExpand
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PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats.
Peroxisome proliferator-activated receptor gamma (PPARgamma), a ligand-activated transcription factor, is considered as an anti-osteoblastic factor associated with adiposity and the elderlyExpand
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Short-time focused ultrasound hyperthermia enhances liposomal doxorubicin delivery and antitumor efficacy for brain metastasis of breast cancer
The blood–brain/tumor barrier inhibits the uptake and accumulation of chemotherapeutic drugs. Hyperthermia can enhance the delivery of chemotherapeutic agent into tumors. In this study, weExpand
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5-Lipoxygenase Inhibitors Attenuate TNF-α-Induced Inflammation in Human Synovial Fibroblasts
The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis. However, theExpand
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Detection of a de novo Y278C mutation in FGFR3 in a pregnancy with severe fetal hypochondroplasia: prenatal diagnosis and literature review.
OBJECTIVE We describe a prenatal molecular diagnosis of hypochondroplasia (HCH) in a pregnancy not at risk of HCH and review the literature on prenatal diagnosis of HCH. CASE REPORT A 28-year-oldExpand
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Involvement of 15‐lipoxygenase in the inflammatory arthritis
15‐Lipoxygenase (15‐LOX) is involved in many pathological processes. The aim of this study is to examine the role of 15‐LOX in the matrix metalloproteinase (MMP) expression and inflammatoryExpand
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15‐deoxy‐Δ12,14‐prostaglandin‐J2 and ciglitazone inhibit TNF‐α‐induced matrix metalloproteinase 13 production via the antagonism of NF‐κB activation in human synovial fibroblasts
Collagenase‐3 (matrix metalloproteinase, MMP‐13) plays an important role in the degradation of cartilage in pathologic conditions. MMP‐13 is elevated in joint tissues in both rheumatoid arthritisExpand
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