—The theory of optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a " switching " controller that can be applied to insulin injection for blood glucose (BG) regulation. The " switching " controller is defined by a collection of basic insulin rates… (More)
— Functional observers estimate a linear function of the state vector directly without having to estimate all the individual states. In the past various observer structures have been employed to design such functional estimates. In this paper we discuss the generality of those various observer structures and prove the conditions under which those observer… (More)
This paper presents a method of controlling the arterial carbon dioxide tension of patients receiving mechanical ventilation. Controlling of the CO2 tension is achieved by regulating the ventilator initiated breath frequency and also volume per breath.