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A refined model of how Yersinia pestis produces a transmissible infection in its flea vector
The present results highlight the physiopathological and molecular mechanisms leading to flea blockage, show that the role of a gene like rpiA changes in space and in time during an infection, and emphasize that evolution is a gradual process punctuated by sudden jumps. Expand
Interplay between Yersinia pestis and its flea vector in lipoate metabolism
Using Yersinia pestis and its flea vector, a bioluminescence-based approach is developed and employed to investigate the mechanisms of pathogenesis at an unprecedented level of detail, finding lipoylation of metabolic enzymes, via the biosynthesis and salvage of lipoate, increases the Y. pestis transmission rate by fleas. Expand