Tylor Drake

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BACKGROUND Carotenoids are hypothesized to explain some of the protective effects of fruit and vegetable intake on risk of cardiovascular disease. The present study assessed the protective effects of the oxygenated carotenoid lutein against early atherosclerosis. METHODS AND RESULTS EPIDEMIOLOGY Progression of intima-media thickness (IMT) of the common(More)
BACKGROUND YM155, a small-molecule survivin suppressor, showed modest single-agent activity in a phase I study of heavily pretreated patients. This study was conducted to determine the activity of YM155 in patients with castration-resistant prostate cancer (CRPC) who received prior taxane therapy. PATIENTS AND METHODS Patients received 4.8 mg/m(2)/day of(More)
Fabrication and readout of devices with progressively smaller size, ultimately down to the molecular scale, is critical for the development of very-high-frequency nanoelectromechanical systems ͑NEMS͒. Nanomaterials, such as carbon nanotubes or nanowires, offer immense prospects as active elements for these applications. We report the fabrication and(More)
BACKGROUND To examine if the metabolic distress after traumatic brain injury (TBI) is associated with a unique proteome. METHODS Patients with severe TBI prospectively underwent cerebral microdialysis for the initial 96 h after injury. Hourly sampling of metabolism was performed and patients were categorized as having normal or abnormal metabolism as(More)
All Rights Reserved iii ACKNOWLEDGEMENTS First of all, I'd like to thank my advisor, Prof. Michael Roukes, who has always been a strong support through all these years of my graduate career, and beyond. During my stay at Condensed Matter Physics at Caltech, I have been privileged to work with, and learn from, other members of the group. Special thanks goes(More)
BACKGROUND Serum total human chorionic gonadotrophin β subunit (hCGβ) level might have prognostic value in urothelial transitional cell carcinoma (TCC) but has not been investigated for independence from other prognostic variables. METHODS We utilised a clinical database of patients receiving chemotherapy between 2005 and 2011 for urothelial TCC and an(More)
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