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α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed newExpand
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Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers
  • S. Wang, Z. Liu, +4 authors A. West
  • Medicine, Biology
  • Acta neuropathologica communications
  • 22 November 2017
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2Expand
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Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
α‐Synuclein (α‐syn) is an abundant presynaptic protein that is the primary constituent of inclusions that define Lewy body diseases (LBDs). In these inclusions, α‐syn is phosphorylated at theExpand
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Elevated LRRK 2 autophosphorylation in brain-derived and peripheral exosomes in LRRK 2 mutation carriers
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2Expand
  • 2