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OBJECTIVES As computing technology and image analysis techniques have advanced, the practice of histology has grown from a purely qualitative method to one that is highly quantified. Current image analysis software is imprecise and prone to wide variation due to common artifacts and histological limitations. In order to minimize the impact of these(More)
Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has suggested that subcellular microcalcifications in the fibrous cap may promote material failure of the plaque, but that large calcifications can stabilize it. Yet the physicochemical mechanisms(More)
OBJECTIVES Angiopoietin-like protein 2 (ANGPTL2), a recently identified pro-inflammatory cytokine, is mainly secreted from the adipose tissue. This study aimed to explore the role of ANGPTL2 in adipose tissue inflammation and macrophage activation in a mouse model of diabetes. METHODOLOGY/PRINCIPAL FINDINGS Adenovirus mediated lacZ (Ad-LacZ) or human(More)
Contents Review 699 Multimodel inference in ecology and evolution: challenges and solutions C. 712 Virulence evolution in response to anti-infection resistance: toxic food plants can select for virulent parasites of monarch butterflies J. C. de Roode, C. L. Fernandez de Castillejo, T. Faits and S. Alizon 723 Environmental gradients structure Daphnia pulex ×(More)
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