Twan L. M Mulder

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OBJECTIVES To improve diagnosis of necrotizing enterocolitis (NEC) by noninvasive markers representing gut wall integrity loss (I-FABP and claudin-3) and gut wall inflammation (calprotectin). Furthermore, the usefulness of I-FABP to predict NEC severity and to screen for NEC was evaluated. METHODS Urinary I-FABP and claudin-3 concentrations and fecal(More)
Chorioallantoic artery blood flow and heart rate were studied in the chick embryo from stage 34 until stage 43 (d 9-16 of 21-d incubation). Baseline blood flow profiles of the chorioallantoic artery were measured with a flow probe (Transonic) in 100 chick embryos. The eggs were opened at the air cell and placed in a small plexiglass box with a continuous(More)
Metabolic compensatory mechanisms may partly account for the decreased vulnerability to hypoxia observed in the developing brain. We used proton magnetic resonance spectroscopy and diffusion-weighted imaging to measure the cerebral concentrations of lactate and other metabolites, as well as the apparent diffusion coefficient (ADC) of tissue water, before,(More)
OBJECTIVE The distribution of cardiac output to different organs is well described in the mammalian fetus. Chick embryos are not often used in perinatal cardiovascular research and therefore it is not known whether they can serve as an animal model for this purpose. In this study we documented cardiac output distribution in chick embryos at increasing(More)