Turkan Dagoglu

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Summary: In adults of several species including man, a small transient decrease in serum calcium concentration follows glucagon administration in doses of 1 to 10 mg/kg. The effects of maturation and insulin on this phenomenon were assessed by comparing the response of newborn and adult rats to equivalent doses of glucagon with and without prior insulin(More)
In adults of several species including man, a small transient decrease in Cas (-ΔCas) follows G doses of 1-10 ug/gm. The effects of maturation and I on this phenomenon were studied in newborn (7 gm, Grp. A) and adult (200 gm., Grp. B) rats. In grp. A -ΔCas was maximal 60′ after 1 ug/gm of G. Adding .01 U/gm of I to this dose of G reduced ACas from -1.75(More)
The appearance of rickets in a 6 year old girl receiving MTX for acute lymphatic leukemia prompted a study of the effects of this compound on calcium transport and bone mineralization in animal models. Five days after a single MTX dose (15 mg/M2 IP) rats showed a 75% decrease in TCa as measured in everted duodenal sacs. A second dose reduced TCa to 8% of(More)
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