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Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.
CD4(+) T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for long-lived antibody responses. However, it remains unclear whetherExpand
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The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
The transcription factor TCF1 determines the degree of CD8+ T cell exhaustion in chronic infection. TCF1 fine-tunes T cell exhaustion Exhaustion of CD8+ T cells is observed in chronic viralExpand
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TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
T follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanismsExpand
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TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation
Tuberous sclerosis complex human disease gene products TSC1 and TSC2 form a functional complex that negatively regulates target of rapamycin (TOR), an evolutionarily conserved kinase that plays aExpand
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Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation
Type I interferon–driven CD8+ T cells suppress neutralizing antibody production during chronic LCMV infection. See related Research Articles by Fallet et al. and Sammicheli et al. and a Focus byExpand
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Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection
Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share transcriptional regulators with memoryExpand
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Cutting Edge: miR-17-92 Is Required for Both CD4 Th1 and T Follicular Helper Cell Responses during Viral Infection
Viral infections induce the differentiation of naive CD4 T cells into two distinct lineages, Th1 cells and T follicular helper (TFH) cells. Two recent studies demonstrated that the microRNA clusterExpand
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mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses
ABSTRACT mTOR has important roles in regulation of both innate and adaptive immunity, but whether and how mTOR modulates humoral immune responses have yet to be fully understood. To address thisExpand
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miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8+ T cell antitumor function by restraining T cell senescence andExpand
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IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection
CXCR5+ TCF1+ CD8+ T cells sustain responses during persistent viral infection and mediate the proliferative burst following anti-PD1 treatment. Huang et al. show that IL-27 supports rapid division ofExpand
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