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- Tuomas Tammela, Kari Alitalo
- Cell
- 2010
The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients… (More)
- Kari Alitalo, Tuomas Tammela, Tatiana V Petrova
- Nature
- 2005
The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence.… (More)
- Tuomas Tammela, Georgia Zarkada, +18 authors Kari Alitalo
- Nature
- 2008
Angiogenesis, the growth of new blood vessels from pre-existing vasculature, is a key process in several pathological conditions, including tumour growth and age-related macular degeneration.… (More)
- Tuomas Tammela, Berndt C. Enholm, Kari Alitalo, Karri Paavonen
- Cardiovascular research
- 2005
The discovery of the vascular endothelial growth factor (VEGF) family members VEGF, VEGF-B, placental growth factor (PlGF), VEGF-C and VEGF-D and their receptors VEGFR-1, -2 and -3 has provided tools… (More)
- Marja Lohela, Maija Bry, Tuomas Tammela, Kari Alitalo
- Current opinion in cell biology
- 2009
Vascular endothelial growth factors and their endothelial tyrosine kinase receptors are central regulators of vasculogenesis, angiogenesis and lymphangiogenesis. VEGF signalling through VEGFR-2 is… (More)
- Peter Baluk, Tuomas Tammela, +11 authors D M Mcdonald
- The Journal of clinical investigation
- 2005
Edema occurs in asthma and other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes. It is unclear to what extent… (More)
- Pipsa Saharinen, Tuomas Tammela, Marika J. Karkkainen, Kari Alitalo
- Trends in immunology
- 2004
- Agnes Machnik, Wolfgang Neuhofer, +19 authors Jens M. Titze
- Nature Medicine
- 2009
In salt-sensitive hypertension, the accumulation of Na+ in tissue has been presumed to be accompanied by a commensurate retention of water to maintain the isotonicity of body fluids. We show here… (More)
- Tuomas Tammela, Georgia Zarkada, +15 authors Kari Alitalo
- Nature Cell Biology
- 2011
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth… (More)
- Tuomas Tammela, Anne M. Saaristo, +7 authors Kari Alitalo
- Nature Medicine
- 2007
Surgery or radiation therapy of metastatic cancer often damages lymph nodes, leading to secondary lymphedema. Here we show, using a newly established mouse model, that collecting lymphatic vessels… (More)