Tuomas Mäntylä

Learn More
Recombinant expression of the norovirus capsid protein VP1 leads to self-assembly of non-infectious virus-like particles (VLPs), which are recognized as promising vaccine candidates against norovirus infections. To overcome the scalability issues connected to the ultracentrifugation-based purification strategies used in previous studies, an anion(More)
Current therapeutic approaches to treat cancer are often hampered by the lack of specificity of the drugs used for therapy. Scavidin, a novel fusion protein expressed on cell membranes, could be utilized for targeting of therapeutic molecules. Scavidin exploits the high binding affinity between avidin and biotin and is capable of mediating endocytosis of a(More)
Temporin A (TA), a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria, is effective against a broad spectrum of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium strains. TA interacts directly with the cell membrane of the microorganism and it(More)
A grid tantahun filament of a dimension of 3 X 4 cm2 was used for diamond synthesis by hotfilament assisted chemical vapour deposition (HFCVD). After proper carburization, the filament could be used for multi-cycles of deposition. By heating the filament to 2400 OC in 8% CH4 mixed with H2. diamond has been deposited at rate of about 5 p / h o u r on (100)(More)
  • 1