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The effect of PACAP, a new VIP-like neuropeptide, on femoral arterial blood flow was studied in anesthetized beagle dogs. Intra-arterial infusion of PACAP38, PACAP27, or VIP (0.25-25 pmol/kg) induced a dose-related increase in femoral blood flow. The dose-response curve for PACAP27 or PACAP38 was similar to that for VIP, but the response to PACAP38 at 25(More)
In an attempt to establish a model for hepatitis C virus (HCV) infection, we produced mice transgenic for the HCV envelope genes, E1 and E2, under the control of a regulatory element from hepatitis B virus. F1-generation mice from the established founders demonstrated expression of both E1 and E2 proteins as glycosylated forms in their organs including the(More)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that stimulates the release of adenohypophyseal hormone from the pituitary in fish. In the goldfish, PACAP induces the release of somatolactin (SL), in particular, from cultured pituitary cells. SL belongs to the growth hormone and prolactin family, and comprises two molecular(More)
1. Morphine inhibited twitch responses of the longitudinal muscle of the guinea pig to electrical stimulation. A concentration-response curve of morphine was partly inhibited by a 60-min pretreatment of ileal strip with 10(-10) M of beta-funaltrexamine (beta-FNA). However, the 60-min pretreatment with a higher concentration (10(-9) M) of beta-FNA had no(More)
In order to discover molecules involved in axonal outgrowth during development of the central nervous system (CNS), monoclonal antibodies (MAbs) were raised against homogenates of the early postnatal rat cerebral cortex. A novel MAb, 5H, was obtained which recognizes a developmentally regulated antigen in the CNS. In the cerebral cortex of postnatal (PN)(More)
1. Some pharmacological properties of newly synthesized derivatives of (-)-6 beta-acetylthionormorphine, AcS-morphine (KT-88), KT-89 and KT-90 and their interactions with opioid receptors were studied. 2. AcS-morphine was about twice as potent as morphine in the inhibitory action of the twitch response of the guinea-pig ileal preparation to electrical(More)
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