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Development of bioartificial renal tubule devices with lifespan-extended human renal proximal tubular epithelial cells.
BACKGROUND The bioartificial renal tubule device is a cell therapy system for renal failure. The major obstacle in the development of the bioartificial renal tubule device is the obtainment of aExpand
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Prevention of LLC-PK(1) cell overgrowth in a bioartificial renal tubule device using a MEK inhibitor, U0126.
A common approach to construct a bioartificial renal tubule system is to utilize renal tubular cells seeded in porous polymer membrane hollow fibers. We have reported that overgrowth of renal tubularExpand
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Suppression of parathyroid hormone production in vitro and in vivo by RNA interference.
We used RNA interference, which causes sequence-specific degradation of target mRNAs to suppress the production of parathyroid hormone by cells of patients with secondary hyperparathyroidism in vitroExpand
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CD133+ endothelial progenitor cells as a potential cell source for a bioartificial glomerulus.
Development of a bioartificial glomerulus, a hemofilter in which the inner surface of hollow fibers is endothelialized, requires expandable, nonimmunogenic, antithrombogenic, and highly permeableExpand
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Enhancement of permeability in endothelial cells for the development of an antithrombogenic bioartificial hemofilter
For the development of an antithrombogenic bioartificial hemofilter, in which the inner surface of hollow fibers is lined by endothelial cells, it is essential to increase the permeability of theExpand
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Basic research in enhancement of permeability in endothelial cells for the development of a bioartificial glomerulus
中空糸モジュール内面にヒト内皮細胞が単層を形成し,抗血栓性であるとともに高透過性能を合わせ持つバイオ人工糸球体を開発するためには,内皮細胞が糸球体内皮細胞のように大きなfenestrae径を有することが必要である.私どもは,actinフィラメントがfenestrae径に関与し,その重合化の阻害剤であるcytochalasinExpand