Tuija Tuunanen

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We performed phototherapeutic keratectomy (PTK) in 39 eyes of 38 patients with various corneal diseases. Patients were divided into four diagnostic entities: group 1 consistent of 11 eyes with postinfectious or posttraumatic corneal scars; 15 eyes with various corneal dystrophies or keratopathies comprised group 2; group 3 consisted to two eyes with(More)
PURPOSE To compare the predictability, safety, and stability of photorefractive keratectomy (PRK) in patient groups with low, moderate, and high myopia. The astigmatic component of these corrections was also evaluated. METHODS In 110 patients, 110 consecutive eyes were operated with a VISX 20/20 excimer laser using standard settings and a 6 mm ablation(More)
BACKGROUND Fibronectin is supposed to have an important role in wound healing. The extradomain A-containing cellular fibronectin (EDAcFn) refers to fibronectin, which instead of being a hepatocyte derived component of blood plasma or body fluids, is produced locally. The present study was undertaken to clarify the possible changes in excretion of EDAcFn in(More)
BACKGROUND The efficacy and safety of excimer laser photoastigmatic refractive keratectomy (PARK) for treatment of astigmatism after penetrating keratoplasty (PKP) was evaluated in this study. METHODS A VisX 20/20 excimer laser was used to correct the regular astigmatic component of the grafts. The epithelium was removed manually in seven cases and in(More)
AIM Weekly paclitaxel is widely used in the treatment of metastatic breast cancer (MBC). Our aim was to test its efficacy and tolerability as a second-line therapy for MBC in daily oncology practice. PATIENTS AND METHODS Paclitaxel (90 mg/m(2)) was given intravenously three times weekly in a 4-week cycle to 91 patients with disease progression after(More)
PURPOSE To evaluate whether relative tear deficiency, indicated by low standardized Schirmer test values, influences the outcome of photorefractive keratectomy (PRK). SETTING Department of Ophthalmology, University of Heisinki, Finland. METHODS Sixty-two patients were pair-matched by age and attempted myopic correction. They were divided into two(More)
PURPOSE To determine whether measurement of intraocular pressure (IOP) using a pneumatonometer is reliable after myopic 5 or 15 D excimer laser photoablation in rabbits. METHODS Ten rabbits underwent 5 D myopic photorefractive keratectomy (PRK) of the left eye. Another seven rabbits underwent 15 D PRK: The right eye served as a control. The diameter of(More)
BACKGROUND Chemotherapy given every third week is currently the mainstay in the treatment of metastatic breast cancer (MBC). However, bi-weekly dosing might offer a better dose intensity, with better tolerability and response rates. This hypothesis was tested in a phase II study on bi-weekly paclitaxel combined with capecitabine. PATIENTS AND METHODS(More)