Tui Neri

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* These authors listed by alphabetical order equally contributed to the major part of this publication Conflicts of interest: The authors have declared that no conflict of interest exists BlinNuryStefanovic et al 40120-RG-1 R4 2 SUMMARY During embryogenesis, the cardiac cell fate is acquired as early as gastrulation. There is compelling evidence that(More)
Autosomal recessive osteopetrosis is a human bone disease mainly caused by TCIRG1 gene mutations that prevent osteoclasts resorbing activity, recapitulated by the oc/oc mouse model. Bone marrow transplantation is the only available treatment, limited by the need for a matched donor. The use of induced pluripotent stem cells (iPSCs) as an unlimited source of(More)
Genomic disorders resulting from large rearrangements of the genome remain an important unsolved issue in gene therapy. Chromosome transplantation, defined as the perfect replacement of an endogenous chromosome with a homologous one, has the potential of curing this kind of disorders. Here we report the first successful case of chromosome transplantation by(More)
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