Tuan Trung Nguyen

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BACKGROUND Cyclophilin inhibitors have shown activity against a variety of viruses, including HCV. NIM811, a novel, non-immunosuppressive cyclophilin inhibitor was studied in ascending doses in a randomized, double-blind, placebo-controlled 14-day trial in genotype 1 HCV patients. Doses of 10 up to 600 mg were given orally once or twice daily as monotherapy(More)
Classification systems working on large feature spaces, despite extensive learning, often perform poorly on a group of atypical samples. The problem can be dealt with by incorporating domain knowledge about samples being recognized into the learning process. We present a method that allows to perform this task using a rough approximation framework. We show(More)
The waiting list for a kidney or simultaneous pancreas-kidney transplant is growing, and waiting times are getting longer. As a consequence, transplant candidates are dying while waiting for a transplant. In a retrospective analysis, we studied whether patients on our list who died while waiting were good candidates. From January 1, 2002, through September(More)
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BACKGROUND IDX184 is a liver-targeted nucleotide prodrug that selectively inhibits HCV NS5B polymerase. METHODS This randomized, double-blind, placebo-controlled, ascending-dose study investigated the antiviral activity, safety and pharmacokinetics of IDX184 plus pegylated interferon-α2a and ribavirin (P/R) in treatment-naive patients with genotype-1 HCV.(More)
Optical Character Recognition (OCR) is a classic example of decision making problem where class identities of image objects are to be determined. This concerns essentially of finding a decision function that returns the correct classification of input objects. This paper proposes a method of constructing such functions using an adaptive learning framework,(More)