• Publications
  • Influence
Quantitative in vivo and in vitro characterization of co-infection by two genetically distant grass carp reoviruses.
Grass carp reovirus (GCRV) is one of the most serious pathogens threatening grass carp (Ctenopharyngodon idella) production in China. Through sequence analysis, the co-existence of two geneticallyExpand
Proteomic identification, characterization and expression analysis of Ctenopharyngodon idella VDAC1 upregulated by grass carp reovirus infection.
TLDR
The present data did demonstrate that CiVDAC1 might be mediated grass carp antiviral immune response, and to interpret the role of other VDAC proteins in viral pathogenesis, CiVDac2 was characterized and showed to respond positively to GCRV challenge, which suggested that CiVVDAC2 might functionally complement CiVD AC1 in C. idella. Expand
Proteomic identification and characterization of Ctenopharyngodon idella tumor necrosis factor receptor-associated protein 1 (CiTrap1): an anti-apoptosis factor upregulated by grass carp reovirus
TLDR
The results of this study suggest that CiTrap1 is involved in the host's innate immune response to viral infection possibly through protecting infected cells from apoptosis. Expand
Proteomic analysis of cellular protein expression profiles in response to grass carp reovirus infection.
TLDR
The expressions of the cellular proteins CiTIA1 and CiG3BP1 in response to GCRV were validated by western blotting, which indicated that the G CRV should unlink TIA1 aggregation and stress granule formation. Expand
A proper PiCAT2 level is critical for sporulation, sporangium function, and pathogenicity of Phytophthora infestans
TLDR
PiCAT2 affects P. infestans sporangial formation and function, pathogenicity, and abiotic stress tolerance by regulating the expression of cell cycle‐related genes (PiCdc14 and PiSDA1) and MAPK pathway genes and provides new insights into catalase functions in eukaryotic pathogens. Expand
Identification of up-regulated proteins potentially involved in the antagonism mechanism of Bacillus amyloliquefaciens G1
TLDR
The proteomic data contribute to a better understanding of the molecular basis for the antagonism of B. amyloliquefaciens and suggest that high levels of energy metabolism, biosynthesis and stress resistance could play important roles in strain G1’s antagonism. Expand
Suppression of RNA interference pathway in vitro by Grass carp reovirus
TLDR
Investigation of Grass carp reovirus replication on the RNAi pathway of grass carp kidney cells indicated that replication of GCRV correlated with the increased transcription level of the Dicer gene and functional inhibition of in vitro synthesized egfp-siRNA in silencing the EGFP reporter gene. Expand
Sequestration of RNA by grass carp Ctenopharyngodon idella TIA1 is associated with its positive role in facilitating grass carp reovirus infection
TLDR
Evidence is provided to show that CiTIA1 bound to synthesized ssRNA and dsRNA in vitro and enhanced the replication efficiency of GCRV in CIK cells, suggesting that cellular CiTia1 might facilitate G CRV replication through sequestrating and protecting viral RNA from degradation. Expand
Antifungal Use for Opportunistic Infection in HIV Patients: Comparison of Efficacy and Safety
TLDR
It is found that different efficacy of different drugs form the basis guideline for the therapeutic regimen in treating opportunistic fungal infections, however, therapeutic regimens recommended also induce various types of adverse reactions or side effects. Expand