Tu-I Tsai

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Second harmonic generation (SHG) has emerged as an important microscopic contrast agent for noninvasive observation of biological tissues with auto-sectioning and deep penetration capabilities. It has been shown that, with unique polarization dependencies of different molecules, the contrast of SHG reflects local arrangement and the crystallization degree(More)
The activities of 23 brain or liver enzymes were studied in 5-6 week old C57BL/6JNctr male and female mice that had been fed ad libitum and standardized for 2 weeks to either (1) 12 hr of light (0600-1800) alternating with 12 hr of darkness (1800-0600) (LD 12:12), (2) staggered sequences of 12 hr of light and 12 hr of dark (SLD 12:12) or (3) continuous(More)
An infradian modulation with a 168 h or circaseptan period characterizes epithelial corneal mitoses in adult female and male Holtzman rats, standardized at 24 +/- 1 degree C and approximately 50% relative humidity on six different sequences of light (L) alternating every 12 h with darkness (D). To approximate sampling over a 24 h LD span by convenient(More)
The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns of DNA synthesis in these organs. The(More)
Epidermal growth factor (EGF) or saline was administered intraperitoneally to hypophysectomized adult male CD2F1 mice or intact controls at 0700 hr. Subgroups of mice were killed at 4, 8, or 12 hr after injection. EGF was shown to stimulate [3H]TdR incorporation into DNA into several organs as previously reported. The response to EGF was found to be(More)
The objective was to determine the effect of adrenocorticotropin (ACTH 1-17) on the incorporation of [3H]TdR into DNA (DNA synthesis) in the tongue, esophagus and stomach of CD2F1 mice standardized to 12 hours of light alternating with 12 hours of darkness. A question asked was whether the time of administration along the 24-hour time scale influenced any(More)