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The purpose of this article is to evaluate in vivo 3-dimensional kinematics of the elbow joint during elbow flexion. We studied the ulnohumeral and radiohumeral joint noninvasively in 3 elbows in healthy volunteers using a markerless bone registration algorithm. Magnetic resonance images were acquired in 6 positions of elbow flexion. The inferred contact(More)
Expression of the pro-inflammatory cytokine interleukin-1 beta (IL-1beta) is increased following the nervous system injury. Generally IL-1beta induces inflammation, leading to neural degeneration, while several neuropoietic effects have also been reported. Although neurite outgrowth is an important step in nerve regeneration, whether IL-1beta takes(More)
BACKGROUND Three-dimensional anatomical correction is desirable for the treatment of a long-bone deformity of the upper extremity. We developed an original system, including a three-dimensional computer simulation program and a custom-made surgical device designed on the basis of simulation, to achieve accurate results. In this study, we investigated the(More)
Methylcobalamin (MeCbl), a vitamin B12 analog, promotes neurite outgrowth by activating Akt in neurons. However, Akt is involved in many cellular functions, and the downstream signal of Akt that promotes neurite outgrowth in neurons in the presence of MeCbl remains obscure. Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that(More)
BACKGROUND Corrective osteotomy using dorsal plates and structural bone graft usually has been used for treating symptomatic distal radius malunions. However, the procedure is technically demanding and requires an extensive dorsal approach. Residual deformity is a relatively frequent complication of this technique. QUESTIONS/PURPOSES We evaluated the(More)
BACKGROUND Many reports have discussed reconstruction of the lateral ulnar collateral ligament for the treatment of posterolateral rotatory instability of the elbow, but information regarding the isometric point of the lateral ligament of the elbow is limited. The purposes of the present study were to investigate the in vivo and three-dimensional length(More)
We report a case of malunited intra-articular fracture of the distal radius successfully treated with corrective osteotomy through an extra-articular approach using a custom-made surgical guide that was designed based on preoperative three-dimensional computer simulation.
BACKGROUND Opening wedge corrective osteotomy usually requires a bone graft. However, it is difficult to shape the graft into an appropriate configuration. To resolve this problem, we developed an original computer program system that calculates the size and shape of a bone graft and cuts a hydroxyapatite block into the desired shape. METHODS Five(More)
PURPOSE The interosseous membrane (IOM) of the forearm is a stout ligamentous complex that reportedly comprises several ligamentous components. The purpose of this cadaveric study was to define all IOM ligaments and to clarify the precise attachment locations. METHODS Thirty forearms from 15 embalmed cadavers were used. After dissection, all IOM ligaments(More)
Several porous calcium hydroxyapatite (HA) ceramics have been used clinically as bone substitutes, but most of them possessed few interpore connections, resulting in pathological fracture probably due to poor bone formation within the substitute. We recently developed a fully interconnected porous HA ceramic (IP-CHA) by adopting the 'foam-gel' technique.(More)